AUTHORS: E. Korobko, S.Vilanskaya, A. Baeshko, N. Shestak
Download as PDF
ABSTRACT: The foam sclerotherapy is a popular and highly effective method of varicose disease treatment allowing to obtain a positive result in more than 80% of cases. The foams characteristics depend on the kind of sclerosant, its concentration, a type of gas, gas/liquid ratio, and the technique of foam preparation. The present investigation, was carried out to assess the influence of temperature on the rheological characteristics of the foam prepared from an aqueous solution of a sclerosant (polidocanol) in conditions of continuous shear deformation. The dependence of the viscosity of the foam on the shear rate was investigated in the specified temperature range 10–25С and in the specified shear range = 3.75–82.5 s-1 by the Brookfield LVDV-III Ultra CP viscometer connected to a Brookfield TC-102 Circulating Bath with Digital Controller. The viscosity of the foam prepared from a polidocanol solution of investigated concentrations (1%, 3%) increases on temperature decrease and concentration increase in the investigated ranges of temperatures and shear velocities, varying within 0.028–0.165 Pa•s.
KEYWORDS: sclerosant, foam, polidocanol, concentration, viscosity, rheological characteristics, temperature
REFERENCES:
[1] Kundu S, Lurie F, Millward SF, et al. 2007. J Vasc Surg. 46(3):582-9.
[2] Ravi M, Kate V, Ananthakrishnan N. 2001. Indian J Med Res 113:228-33.
[3] McAree B1, Ikponmwosa A, Brockbank K, et al. Eur J Vasc Endovasc Surg 43(6):721-5
[4] Eckmann DM. 2009. Expert Opin Investig Drugs 18(12): 1919–1927.
[5] Hamel-Desnos C., Allaert F.A. 2009. Phlebology 24(6):240-6.
[6] Rasmussen L.H., Lawaetz M, Bjoern L., et al. 2011. Br J Surg 98(8):1079-87
[7] Parsi K. 2015. Phlebology 30, 5, 306–315
[8] Cavezzi A, Tessari L. 2009. Phlebology 24: 247-251.
[9] Hesse G., Breu F.X., Kuschmann A., et al. 2012. Phlebologie 2; 41: 77–88.
[10] Peterson J.D. Goldman M.P. 2011. Dermatol Surg 37(1):12-7.
[11] Rabe E, Breu FX, Cavezzi A, et al. 2014. Phlebology 29(6):339-54.
[12] Ceulen R.P., Bullens-Goessens Y.I., Pi-VANDE Venne S.J., et al. 2007. Dermatol Surg 33(3):276-81.
[13] Valenzuela GC, Wong K, Connor DE, et al. 2013. Eur J Vasc Endovasc Surg 46(5):593-9.
[14] Brookfield DV-III Ultra Programmable Rheometer/Operating Instructions. Manual No. М/98-211-В0104 – 122 p.
[15] Reference Book for Chemists 1962 vol 1 (Moscow: Goschimizdat) p 985.
[16] Smolskii B.M., Shulman Z.P., Gorislavets V.M. 1970 Rheodynamics and heat transfer of nonlinear viscoplastic materials (Minsk: Nauka i Technika).
