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Vittorio Ingegnoli
Elena Giglio

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Vittorio Ingegnoli
Elena Giglio

WSEAS Transactions on Environment and Development

Print ISSN: 1790-5079
E-ISSN: 2224-3496

Volume 13, 2017

Notice: As of 2014 and for the forthcoming years, the publication frequency/periodicity of WSEAS Journals is adapted to the 'continuously updated' model. What this means is that instead of being separated into issues, new papers will be added on a continuous basis, allowing a more regular flow and shorter publication times. The papers will appear in reverse order, therefore the most recent one will be on top.

Volume 13, 2017

Complex Environmental Alterations Damages Human Body Defence System: a New Bio-Systemic Way of Investigation

AUTHORS: Vittorio Ingegnoli, Elena Giglio

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ABSTRACT: Few studies focus on environment in its biological dimension, relating territorial/landscape alteration and human health, beyond pollution impact. The growing importance of risk factors in medicine and the new ecological advancements in Landscape Bionomics impose to deepen these studies. The landscape is a living entity, in which man and territory form a complex biological level of life organization. So, a landscape must be investigated in its physiology and behaviour by the discipline of Landscape Bionomics. This to check “if”, “how” and “how much” landscape alterations could reflect on human health, independently form pollution. First evidences of a clear correlation subsist, concerning an increase of mortality rate within Milan hinterland (Italy). The Landscape dysfunctions are correlated with the increase of mortality rate MR. All the environmental alterations are registered as ‘stressors’ by a basilar ethological alarm process. So, bionomic landscape dysfunctions may attempt our health bringing to an excess of cortisol, which reduces our hormonal, immune and nervous system defences. This enlarges the W.H.O. estimation of the environmental MR and the importance of applications impose a true effort in landscape rehabilitation.

KEYWORDS: scientific paradigm, ecology, bionomics, landscape, vegetation science, human health, complex systems, psycho-neuro-endocrine-immunology


[1] W.H.O. (2011) Public Health and Environment, Global Strategy Overview. World Health Organisation, Geneva

[2] W.H.O. (2014) Seven million premature deaths annually linked to air pollution. World Health Organisation, Geneva

[3] Meffe GK, Carroll CR (1997) Principles of conservation biology. Sinauer Associates Inc Publ, Sunderland, Massachusetts

[4] Ingegnoli V. (1991) Human influences in landscape change: thresholds of metastability. in: O Ravera (ed.) Terrestrial and aquatic ecosystems: perturbation and recovery. Ellis Horwood Ltd., Chichester, England pp. 303-309

[5] Ingegnoli V (2001) Landscape Ecology. in: D Baltimore, R Dulbecco, F Jacob, R Levi-Montalcini (eds.) Frontiers of Life. vol IV. Academic Press, Boston, pp. 489-508.

[6] Ingegnoli V (2015) Landscape Bionomics. Biological-Integrated Landscape Ecology. SpringerVerlag, Heidelberg, Milan, New York, pp. XXIV+431

[7] Ingegnoli V (2002) Landscape Ecology: A Widening Foundation. Springer-Verlag, Berlin, Heidelberg, New York, pp. XXIII+357

[8] Ingegnoli V, Giglio E (2005) Ecologia del paesaggio: manuale per conservare, gestire e pianificare l’ambiente. Simone Edizioni-Esse Libri, Napoli, pp. 685+XVI

[9] Maas J, Verhij RA, Groenewegen PP, de Vries S, Spreeuwenberg P (2006) Evidence based public health policy and practice. Green space, urbanity and health: how strong is the relation? J Epidemiol Community Health. Vol. 60, pp. 587-592. doi:10.1136/jech. 2005. 043125

[10] Mitchell R, Popham F (2008) Effect of exposure to natural environment on health inequalities: an observational population study. Lancet, Vol. 372, pp1655-1660 (Issue 9650)

[11] Nieuwenhuijsen MJ, Kruize H, Gidlow C et al. (2014) Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): a study programme protocol. BMJ Open. Vol. 4, e004951 doi:10. 1136/bmjopen-2014-004951

[12] Lorenzini G, Nali C (2005) Le piante e l’inquinamento dell’aria. Springer-Verlag, Milano

[13] Bottaccioli F (2014) Epigenetica e Psiconeuroendocrino-immunologia; le due facce della Rivoluzione in corso nelle scienze della vita. Edra Spa, Milano, pp.192

[14] Selye H (1956) The Stress of Life. Mc GrawHill, New York

[15] Altman J. (1963) Autoradiographic investigationof the cell proliferation in the brains of rats and cats. Anathomy Reasearch145:573-591

[16] Holliday R (2006) Epigenetics: a historical overview. Epigenetics, Vol. 1, pp. 76-80

[17] Crick F (1970) Central Dogma of Molecular Biology. Nature, Vol. 227, pp. 561-563

[18] Ingegnoli V (2011) Bionomia del paesaggio. L’ecologia del paesaggio biologico-integrata per la formazione di un “medico” dei sistemi ecologici. Springer-Verlag. Milano, pp. XX+347

[19] Naveh Z, Lieberman A (1984) Landscape Ecology: theory and application. Springer-Verlag New York, Inc, pp.

[20] Naveh Z, Lieberman A (1994) Landscape Ecology: theory and application. Springer-Verlag New York, Inc, pp.

[21] Pignatti S, Box EO, Fujiwara K (2002) A new paradigm for the XXIth Century. Annali di Botanica, Vol. II, pp. 31-58

[22] Ingegnoli V (2005) An innovative contribution of landscape ecology to vegetation science. Israel Journal of Plant Sciences. Vol. 53, pp. 155-166

[23] Ingegnoli V, Pignatti S (2007) The impact of the widened Landscape Ecology on Vegetation Science: towards the new paradigm. Springer Link: Rendiconti Lincei Scienze Fisiche e Naturali. s.IX, vol.XVIII, pp. 89-122

[24] Ingegnoli V (1999) Definition and Evaluation of the BTC (Biological Territorial Capacity) as an Indicator for Landscape Ecological Studies on Vegetation. in: W Windhorst, PH Enckell (Eds) Sustainable Landuse Management: The Challenge of Ecosystem Protection. EcoSys: Beitrage zur Oekosystemforschung, Suppl Bd 28, pp. 109-118

[25] Ingegnoli V, Giglio E (1999) Proposal of a synthetic indicator to control ecological dynamics at an ecological mosaic scale. Annali di Botanica. Vol. LVII, pp. 181-190

[26] DUSAF (2010) Uso del suolo in Regione Lombardia. Regione Lombardia, Milano

[27] European Space Agency (2004) Annual Report. Paris

[28] Ingegnoli V (2013) Concise evaluation of the bionomic state of natural and human vegetation elements in a landscape. Rend. Fis. Acc. Lincei; doi 10.1007/s12210-013-0252-2

[29] Lorenz K. Vergleichende Verhaltensforschung: Grundlagen der Ethologie. Springer-Verlag, Berlin, Wien; 1978

[30] Hiramoto RN, Solvason HB, Hsueh CM (1999) Psychoneuro-endocrine immunology: perception of stress can alter body temperature and natural killer cell activity. Int. J. Neurosci. Vol. 98 (1-2): 95-129

[31] Slavich GM, Way BM, Eisenberger NI, Taylor SE (2010) Neural sensitivity to social rejection is associated with inflammatory responses to social stress. PNA, Vol. 107 (33), pp. 14817-14822 doi: 10.1073/pnas.1009164107

[32] Berne RM, Levy MN (1990) Principles of Physiology. The CV Mosby Company. U.S.A

[33] Genuth SM (1990) The Adrenal Medulla. in: RM Berne, MN Levy. Principles of Physiology. The CV Mosby Company, USA, pp. 572- 578

[34] Hansel A, Hong S, Càmara RJ, von Kanel R (2010) Inflammation as a psychophysiological biomarker in chronic psychological stress. Neuroscience and Biobehavioral Reviews. Vol. 35, pp. 115-121

[35] Bottaccioli F (2012) Stress e Vita. La scienza dello stress e la scienza della salute alla luce della Psiconeuroendocrinoimmunologia. Tecniche Nuove, Milano

[36] Melse JM, de Hollander AEM (2001) Human Health and the Environment. Background document for the OECD. Environmental Outlook, OECD, Paris

[37] Gogtay N, Giedd JN, Lusk L et al (2009) Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences of the United States of America. Vol. 101 (21), pp. 8174- 8179

[38] Diamanti-Kandarakis E, Bourguignon JP, Giudice LC et al.(2009) Endocrine-disrupting chemicals: an Endocrine Society Scientific Statement. Endocr Rev. 2009; Vol. 30 (4), pp. 293-342 doi: 10.1210/en.2009-0002.

[39] Magro G. et al. (2007) Quantifying Cumulative Impact Assessment with Dynamic Computational G.I.S. System in a multi stressor area: a case study on a waste treatment plant in Italy. Annual Conference “Growth, Conservation and Responsibility”, IAIA Seoul, Corea

[40] Ingegnoli V, Giglio E (2016) Landscape project can limit bionomics dysfunction risk factor Vs. premature death increase. Modern Environmental Science and Engineering, vol. 2 (7): 435-444. Academic Star Publishing Company, USA; doi 10.15341/mese(2333-2581)/07.02.2016/001

[41] Szif M, McGowan P, Meaney M (2008) The social environment and epigenome. Environmental and Mol Mutagenesis, vol. 49, pp. 46-60. and Mol Mutagenesis, vol. 49, pp. 46-60. and Mol Mutagenesis, vol. 49, pp. 46-60.

WSEAS Transactions on Environment and Development, ISSN / E-ISSN: 1790-5079 / 2224-3496, Volume 13, 2017, Art. #19, pp. 170-180

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