AUTHORS: Elena V. Pereverzeva, Anastasiya Yu. Gulko, Yury E. Vabishevich, Menizibeya O. Welcome, Anatoly V. Sikorsky, Vladimir A. Pereverzev
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ABSTRACT: Glomerular filtration rate (GFR) was investigated with different methods in hypertensive young men (18- 27 years) who never had primary disease of the kidney. GFR was evaluated by Rehberg method, Cockcroft-Gault formula, MDRD (Modification of diet in renal disease) formula, MDPvD (methylenedioxypyrovalerone) formula, CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula. The normalization of GFR to a standardized body surface area of 1.73 m2. The study showed no significant difference in the mean values of GFR calculated by Rehberg and Cockcroft-Gault formula. The GFR obtained by MDRD, MDPvD, CKD-EPI were respectively lower by 15.5%, 15.6% and 10.0%, compared with the result of the Rehberg method. Similar result was obtained when compared with the values calculated by the Cokcroft-Gault formula: GFR calculated by MDRD, MDPvD, CKD-EPI were respectively lower by 16.0%, 16.1% and 10.4%, respectively. In conclusion, GFR can better be determined in first degree hypertensive patients using Rehberg method or the Cokcroft Gault formula.
KEYWORDS: Glomerular filtration rate; Cockcroft-Gault; MDRD; MDPvD; CKD-EPIREFERENCES:
 E. V. Shlyakhto, A. O. Konradi, N. E. Zvartau, “Arterial hypertension. Cardiology: national reference,” 2 nd ed., Ed. E. V. Shlyakhto. Moscow, GEOTAR-Media, 2015.
 V. P. Tsaryov, “Laboratory workshop on propaedeutics of internal diseases,” Minsk, BSMU press, 2004.
 R. G. Oganov, M. N. Mamedov, “National clinical recommendations,” Moscow, Russian Scientific Society of Cardiology, 2009.
 A. V. Smirnov, E. M. Shilov, V. A. Dobronravov, “National recommendations. Chronic kidney disease: the basic principles of screening, diagnosis, prevention, and approaches to treatment,” Clin. Nephrol., no. 4, pp.4-26, 2012.
 D. W. Cockroft, M. H. Gault, “Prediction of creatine cleareance from serum creatitnine,” Nefron, vol. 16, no. 1, pp. 31-41, 1976.
 M. H. Gault, “Predicting glomerular function from adjusted serum creatinine,” Nefron, no. 2, pp. 249- 256, 1992.
 K. Matsushita, B. K. Mahmodi, M. Woodward et al. , “Comparison of the risk prediction using the CKDEPI equation and the MDRD study equation for estimated glomerular filtration rate,” JAMA, vol. 307, pp. 1941-1951, 2012.
 A. A. Bova, “Chronic renal failure and chronic kidney disease: correlation of terms,” Military Med., no. 1, pp. 25-34, 2012.
 V. M. Zaitsev, V. G. Liflyandsky, V. I. Marinkin, “Applied medical statistics,” Foliant, St. Petersburg, 2006.