Plenary Lecture

Multimodality Molecular Imaging: Paving the Way for Personalized Medicine

Professor Habib Zaidi
Division of Nuclear Medicine and Molecular Imaging
Geneva University Hospital
Department of Nuclear Medicine and Molecular Imaging
University of Groningen
The Netherlands
Department of Nuclear Medicine
University of Southern Denmark

Abstract: Early diagnosis and therapy increasingly operate at the cellular, molecular or even at the genetic level. As diagnostic techniques transition from the systems to the molecular level, the role of multimodality molecular imaging becomes increasingly important. Positron emission tomography (PET), x-ray CT and MRI are powerful techniques for in vivo imaging. The inability of PET to provide anatomical information is a major limitation of standalone PET systems. Combining PET and CT proved to be clinically relevant and successfully reduced this limitation by providing the anatomical information required for localization of metabolic abnormalities. However, this technology still lacks the excellent soft-tissue contrast provided by MRI. Standalone MRI systems reveal structure and function, but cannot provide insight into the physiology and/or the pathology at the molecular level. The combination of PET and MRI, enabling truly simultaneous acquisition, bridges the gap between molecular and systems diagnosis. MRI and PET offer richly complementary functionality and sensitivity; fusion into a combined system offering simultaneous acquisition will capitalize the strengths of each, providing a hybrid technology that is greatly superior to the sum of its parts. This talk also reflects the tremendous increase in interest in quantitative molecular imaging using PET as both clinical and research imaging modality in the past decade. It offers a brief overview of the entire range of quantitative PET imaging from basic principles to various steps required for obtaining quantitatively accurate data from dedicated standalone PET and combined PET/CT and PET/MR systems including algorithms used to correct for physical degrading factors and to quantify tracer uptake and volume for radiation therapy treatment planning. Future opportunities and the challenges facing the adoption of multimodality imaging technologies and their role in biomedical research will also be addressed.

Brief Biography of the Speaker: Habib Zaidi is Professor at the medical school of Geneva University and head of the PET Instrumentation & Neuroimaging Laboratory at Geneva University Hospital. He is also a Professor of Medical Physics at the University Medical Center of Groningen, Adjunct Professor of Medical Physics and Molecular Imaging at the University of Southern Denmark and Adjunct Professor of Medical Physics at Shahid Beheshti University. He is actively involved in developing imaging solutions for cutting-edge interdisciplinary biomedical research and clinical diagnosis in addition to lecturing undergraduate and postgraduate courses on medical physics and medical imaging. His research is supported by the Swiss National Foundation and the Swiss Cancer research foundation (Total 4.65 M US$) and centres on hybrid imaging instrumentation (PET/CT and PET/MRI), modelling medical imaging systems using the Monte Carlo method, development of computational anatomical models and radiation dosimetry, image correction, reconstruction, quantification and kinetic modelling techniques in emission tomography as well as statistical image analysis in molecular brain and oncologic imaging, and more recently on novel design of dedicated PET and PET/MRI scanners. He was guest editor for 10 special issues of peer-reviewed journals dedicated to Medical Image Segmentation, PET Instrumentation and Novel Quantitative Techniques, Computational Anthropomorphic Anatomical Models, Respiratory and Cardiac Gating in PET Imaging, Evolving medical imaging techniques, Trends in PET quantification (2 parts), PET/MRI Instrumentation and Quantitative Procedures and Clinical Applications, and Nuclear Medicine Physics & Instrumentation and serves as Deputy Editor for the British Journal of Radiology and member of the editorial board of Medical Physics, Nuclear Medicine Communications, Clinical and Translational Imaging, American Journal of Nuclear Medicine and Molecular Imaging, International Journal of Molecular Imaging, Biomedical Imaging and Intervention Journal, the Open Medical Imaging Journal, the Open Neuroimaging Journal, International Journal of Biomedical Engineering and Consumer Health Informatics and Medical Physics Journal. He is also a and serves as Associate editor for the International Journal of Biomedical Imaging, the International Journal of Tomography & Simulation and the Journal of Engineering & Applied Sciences and scientific reviewer for leading journals in medical imaging. He has been elected as senior member of the IEEE and liaison representative of the International Organization for Medical Physics (IOMP) to the World Health Organization (WHO) in addition to being affiliated to several International medical physics and nuclear medicine organisations. He is developer of physics web-based instructional modules for the RSNA and Editor of IPEM’s Nuclear Medicine web-based instructional modules. He is also He is involved in the evaluation of research proposals for European and International granting organisations and participates in the organisation of International symposia and top conferences as member of scientific committees. His academic accomplishments in the area of quantitative PET imaging have been well recognized by his peers and by the medical imaging community at large since he is a recipient of many awards and distinctions among which the prestigious 2003 Young Investigator Medical Imaging Science Award given by the Nuclear Medical and Imaging Sciences Technical Committee of the IEEE, the 2004 Mark Tetalman Memorial Award given by the Society of Nuclear Medicine, the 2007 Young Scientist Prize in Biological Physics given by the International Union of Pure and Applied Physics (IUPAP), the prestigious (100’000$) 2010 kuwait Prize of Applied sciences (known as the Middle Eastern Nobel Prize) given by the Kuwait Foundation for the Advancement of Sciences (KFAS) for "outstanding accomplishments in Biomedical technology", the 2013 John S. Laughlin Young Scientist Award given by the American Association of Physicists in Medicine (AAPM), the 2013 Vikram Sarabhai Oration Award given by the Society of Nuclear Medicine, India (SNMI) and the 2015 Sir Godfrey Hounsfield Award given by the British Institute of Radiology (BIR). Dr. Zaidi has been an invited speaker of over 110 keynote lectures and talks at an International level, has authored over 470 publications, including 220 peer-reviewed journal articles in prominent journals (ISI-h index=34 ‒ Web of Science™, >7’900+ citations ‒ Google scholar), 220 conference proceedings and 30 book chapters and is the editor of three textbooks on Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine, Quantitative Analysis in Nuclear Medicine Imaging and Molecular Imaging of Small Animals.

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