Plenary Lecture

Computer-Aided Pathological Image Analysis to Assist in Oncological Diagnostics

Professor Wlodzimierz Klonowski
Nalecz Institute of Biocybernetics and Biomedical Engineering
Polish Academy of Sciences
Warsaw, Poland

Abstract: Highly trained pathologists are indispensable in oncological diagnostics. If a tumor is diagnosed sufficiently early then reasonable treatment and supportive measures may quickly be employed and majority of early recognized cases can be cured. But pathologists spend a lot of their time sieving through benign tissue and there is also considerable interobserver variation in tumor classification and grading. To help out with oncological diagnosis we have proposed new quantitative methods of assessment and classification of selected tumors, methods based on computer-aided analysis of histopathological images. In particular we applied our own method called Image Landscapes’ Fractal Dimension method (ILF) that consists in constructing from the analyzed 2-D image of two 1-D sequences that we call landscapes, which are subsequently analyzed using Higuchi fractal dimension method. ILF may be applied to diagnosis of tumors like lymphomas since it does not require preliminary marking of the tumor’s contour that is rather complicated task even for massive tumors. Our studies have demonstrated significant correlation between tumor grading made by trained pathologists and results obtained with ILF method in grading Anal Intraepithelial Neoplasia (AIN). We also propose new methods of quantitative image-based assessment of colour tissue histopathology slides. Additional information contained in such slides that results from staining tissues from biopsies with different dyes helps to reveal details that might otherwise not be apparent. We demonstrated that with appropriate image preprocessing our methods help out in diagnosis of Diffuse Large B-Cell Lymphoma (DLBCL or DLBL). In collaboration with pathologists and oncologists our computer-aided methods may be adapted and adjusted to help out in diagnosis of other types of tumors.

Brief Biography of the Speaker: Wlodzimierz Klonowski, Ph.D., D.Sc. holds a Master of Science (M.S.) in Physics with specialization in Biophysics, from the University of Warsaw (1968), Doctor of Philosophy (Ph.D.) from the Institute of Physics, Polish Academy of Sciences (1973), and Doctor of Science (D.Sc., Dr Hab.) in Biophysics from Humboldt University, Berlin (1990). He has worked in Africa, as a professor of Physics in the French-speaking l’Univesité National du Zaïre a Kinshasa (now Republic of Congo), in Germany as a Max Planck Fellow at MPI fűr Biophysikalische Chemie in Goettingen, in USA as a visiting professor at Brandeis University in Waltham, MA, in Canada as the President of Canadian Consulting and Tutoring Services at Halifax, NS. He is currently with the Nalecz Institute of Biocybernetics and Biomedical Engineering Polish Academy of Sciences in Warsaw.
In addition to being a researcher, a professor, and an author, he has been a distinguished member of several organizations including Polish Physical Society, European Physical Society, New York Academy of Sciences, American Association of University Professors, and American Association for the Advancement of Science. He is a Bio-Scientific Advisory Board Member of the International Brain Research Foundation Inc. New York, Vice-President and Board Member of the International Consortium for Uncertainty Theory (ICUT), and a Board Member of the International Association for Information and Management Sciences (IMS), Beijing.
He has been active for more than 40 years in the theory of complex nonlinear systems, in particular in application of deterministic chaos theory in biomedicine. He was an initiator and organizer of a series of European Summer Schools EUROATTRACTOR. He has considerably contributed to the theory of structure-property relationships in crosslinked polymer materials through his topological theory of networks, so called Systems with Discrete Interactions. Currently, he is involved in the research on nonlinear methods (in particular fractal methods) in medicine and medical diagnostics - biosignal (EEG, HRV) analysis with applications in patient monitoring (e.g. of the depth of anesthesia) and in assessment of pharmaco-therapies, as well as image analysis in histopathological diagnosis of cancer. He has also lectured in several interdisciplinary conferences.
While fighting against a ’linear way of thinking’ that he calls ‘Human Linearity Virus infection’, Prof. Klonowski has become the Founding Editor and an Editor-in-Chief of EPJ Nonlinear Biomedical Physics (an interdisciplinary open access journal, SpringerOpen, Heidelberg, previously with BioMed Central, London). His biograms are included in several European and American Who’s Who’s, in Wikipedia, and he has a molecular informational structure named after him (Klonowski-Klonowska Conformon, term proposed by S.Ji in ‘Molecular Theories of Cell Life and Death’, Rutgers U. Press, 1991). W.Klonowski is also interested in philosophical problems, in particular in theory of consciousness, and emotions vs logical thinking, that he proposed to call Chaosensology.

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