AUTHORS: Daniah Tahir, Abid Ali Lashari, Kazeem Oare Okosun

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ABSTRACT: This paper considers a mathematical model based on the transmission dynamics of Hepatitis C virus (HCV) infection. In addition to the usual compartments for susceptible, exposed, and infected individuals, this model includes compartments for individuals who are under treatment and those who have had vaccination for HCV. It is assumed that the immunity provided by the vaccine fades with time. The basic reproduction number, R0, and the equilibrium solutions of the model are determined. The model exhibits the phenomenon of backward bifurcation where a stable disease-free equilibrium co-exists with a stable endemic equilibrium whenever R0 is less than unity. It is shown that only the use of a perfect vaccine can eliminate backward bifurcation completely. Furthermore, a unique endemic equilibrium of the model is proved to be globally asymptotically stable under certain restrictions on the parameter values. Numerical simulation results are given to support the theoretical predictions

KEYWORDS: epidemiological model; equilibrium solutions; backward bifurcation; global asymptotic stability; Lyapunov function

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