AUTHORS: Krasimira Prodanova
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ABSTRACT: For the multiple drug administration it is important from therapeutic reasons to maintain the concentration in the blood plasma in an appropriate range. The effectiveness and toxicity of antibiotics and especially of aminoglycosides show a strong direct positive relationship with blood drug concentrations, therefore, therapy with aminoglycosides in adults is usually guided by therapeutic drug monitoring. In the present paper an optimization approach was developed to determine Amikacin dosage regimen to achieve the desired plasma concentrations after application from depot. The developed methodology allows the optimization of both the dose and the dosage interval. Performance of the developed methodology was evaluated by computing bias and precision of the estimated trough and peak Amikacin concentrations that were reached after dosage regimen determinations
KEYWORDS: optimization of multiple drug administration, individualization of drug therapy
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