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Krasimira Prodanova

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Krasimira Prodanova

WSEAS Transactions on Biology and Biomedicine

Print ISSN: 1109-9518
E-ISSN: 2224-2902

Volume 15, 2018

Notice: As of 2014 and for the forthcoming years, the publication frequency/periodicity of WSEAS Journals is adapted to the 'continuously updated' model. What this means is that instead of being separated into issues, new papers will be added on a continuous basis, allowing a more regular flow and shorter publication times. The papers will appear in reverse order, therefore the most recent one will be on top.

Optimizing Multiple Drug Administration from Depot by Applying Pharmacokinetic Concepts

AUTHORS: Krasimira Prodanova

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ABSTRACT: For the multiple drug administration it is important from therapeutic reasons to maintain the concentration in the blood plasma in an appropriate range. The effectiveness and toxicity of antibiotics and especially of aminoglycosides show a strong direct positive relationship with blood drug concentrations, therefore, therapy with aminoglycosides in adults is usually guided by therapeutic drug monitoring. In the present paper an optimization approach was developed to determine Amikacin dosage regimen to achieve the desired plasma concentrations after application from depot. The developed methodology allows the optimization of both the dose and the dosage interval. Performance of the developed methodology was evaluated by computing bias and precision of the estimated trough and peak Amikacin concentrations that were reached after dosage regimen determinations

KEYWORDS: optimization of multiple drug administration, individualization of drug therapy


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WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 15, 2018, Art. #9, pp. 81-86

Copyright © 2018 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution License 4.0

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