AUTHORS: Ivan Todorin, Nicola Yanev, Metodi Traykov, Borislav Yurukov

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ABSTRACT: The proposed model takes into account highest degree of complexity – different size of radiuses of side-chains, mentioned below as radicals, and two stages of algorithm, including random structure initially and subsequent purposeful folding process according to the physical forces and energies. The objective function is three-componential – one member corresponding to the impact of the hydrophobic contacts of side-chains, next one to the impact of hydrogen bonds between peptide chain parts and third to the impact of S-S bridges

KEYWORDS: - Protein folding prediction, Bioinformatics, Drug Design, Willpower folding, HP model, Amino acid descriptors, S-S bridges

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