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Igor Neelov
Elena Popova

Author(s) and WSEAS

Igor Neelov
Elena Popova

WSEAS Transactions on Biology and Biomedicine

Print ISSN: 1109-9518
E-ISSN: 2224-2902

Volume 14, 2017

Notice: As of 2014 and for the forthcoming years, the publication frequency/periodicity of WSEAS Journals is adapted to the 'continuously updated' model. What this means is that instead of being separated into issues, new papers will be added on a continuous basis, allowing a more regular flow and shorter publication times. The papers will appear in reverse order, therefore the most recent one will be on top.

Complexes of Lysine Dendrimer of 2nd/3rd Generations and Semax Peptides. Molecular Dynamics Simulation

AUTHORS: Igor Neelov, Elena Popova

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ABSTRACT: Complexes of lysine dendrimer and nootropic Semax peptides were studied using molecular dynamics simulation. These dendrimers were used for drug and other molecules delivery to different cells. It was shown earlier that dendrimers and in particular lysine dendrimers could penetrate blood brain barrier. In present paper three systems containing lysine dendrimers of 2nd and 3rd generations and 8, 16 or 24 oppositely charged Semax peptides were studied. It was obtained that lysine dendrimers of both generations attracts Semax peptides and forms stable nanocomplexes with peptides. The sizes and structures of these nanocomplexes were investigated. These complexes can be used in future for delivery of Semax peptides to brain since these peptides have significant neuroprotective effects.

KEYWORDS: lysine dendrimer, Semax peptides, computer simulation, molecular dynamics


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WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 14, 2017, Art. #11, pp. 75-82

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