WSEAS Transactions on Biology and Biomedicine

Print ISSN: 1109-9518
E-ISSN: 2224-2902

Volume 14, 2017

Notice: As of 2014 and for the forthcoming years, the publication frequency/periodicity of WSEAS Journals is adapted to the 'continuously updated' model. What this means is that instead of being separated into issues, new papers will be added on a continuous basis, allowing a more regular flow and shorter publication times. The papers will appear in reverse order, therefore the most recent one will be on top.

Paper Based Magnetic Nanoparticles Biosensor for Rapid Prostate Specific Antigen Detection

AUTHORS: Ghadeer A. R. Y. Suaifan, Mohammed Zourob

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ABSTRACT: Paper-based magnetic nanoparticle biosensor for the evaluation of active PSA level was designed. This biosensing configuration is based on the detection of PSA amylodic activity using a specific peptide substrate, sandwiched between magnetic nanonanoparticles and gold sensing platform placed on the top of a paper support. Upon PSA addition, an external magnet fixed at the back of the sensor support would accelerate the cleavage of the magnetic nanoparticles-peptide moieties away from the surface. Colorimetric change from black to golden color was visualized by the naked eye. This biosensor was amenable for a qualitative and quantitative PSA detection in buffer and in spiked urine samples with a lower detection limit of 1 ng/mL and 5 ng/mL, respectively. In conclusion, the designed colorimetric biosensor pinpointed superiority in criteria's including sensitivity; simplicity and fast processing time.

KEYWORDS: Protease, Prostate Cancer, Prostate Specific Antigen, Colorimetric, Biosenser, Magnetic nano-particles


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WSEAS Transactions on Biology and Biomedicine, ISSN / E-ISSN: 1109-9518 / 2224-2902, Volume 14, 2017, Art. #9, pp. 65-68

Copyright © 2017 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution License 4.0

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