Special Session

Information Processing in Biomedical Systems

Professor Jelenka Savkovic-Stevanovic
Faulty of Technology and Metallury
Belgrade University
Karnegijeva 4, 11000 Belgrade
Serbia
E-mail: savkovic@tmf.bg.ac.rs

This proposal presents an integrative framework describing medical information processing. It provides a general bases for thinking about concept the DNA biopolymer molecules and health. Due to rapid advances in chemical and biochemical sequencing techniques, complete nucleotide sequencies of several DNAs were examined. Thus it has become possible to compare calculated with measured profles for known sequenced DNA species or restriction fragments. The two complementary strands comprising the double helix can be separated into single stranded random coils in various ways. Since the random coils have a larger degree of conformational freedom than the ordered double-stranded structure, the ordered structure is disrupted with an increase in temperature or denaturing agents. Investigation in the frame of this session involves simulation of the dissociation-association processes of the complementary strands. At the final step of melting DNA, the complementary strands are dissociated from each other. Relationship between triplet stability and genetic code was discussed. The biomedical important is de novo synthesis which is permiting purine and pyrimidine analogs with potential as anticancer drugs to be incorporated into DNA. The rates of synthesis of purine and pyrimidine oxy- and deoxyribonucleotides are subject to precise regulation. Neither nucleotides nor their parent purine and pyrimidine bases in the diet are incorporated into human tissue nucleic acids or into purine or pyrimidine coenzymes. In the frame of this session database for general health state as well as distribution disease simulation were provided. Randomized controlled trials in women with either early breast cancer or advanced breast cancer comparing: treatment with a drug with the same treatment without a drug, treatment with one drug with treatment with a different drug. Studies including at least one of the following outcome were considered for evaluation sceletal events, quality of life, bone pain, and survival.

Topics:

• Data base structure in pathology

• Decision support system in lung cancer diagnosis

• Tissue information processing

• Biomedical parameters characterization

• Information system for population data reduction

• Purine an pyrimidine metabolisms

• Local helix stability of natural DNA

• Effects of doublet DNA reassociation and association

Brief Biography of the Speaker:
Full professor, University of Belgrade, Faculty of Technology and Metallurgy, Serbia. Education: B.Sc. and M.Sc. degree, University of Belgrade, PhD Thesis Technical University of Berlin and University of Belgrade. Research interest: Chemical Engineering and Process System Engineering; Modelling, Analysis, Synthesis, Design,
Process optimization; Advanced numerical methods, Control and On-line optimization; Computer Aided Process Operation and Design, Safety and Risk analysis; Information System, Data base, Expert systems, Learning Systems; Informatics, Management; Artificial Intelligence, Neural Networks and Fuzzy logics; Biosystems, Bioinformatics, Pharmaceutical and Biomedical Engineering. Other professional activites: Over 800 papers, 8 books, patentees in the field, Consultant in many companies, Member of many professional organizations, Reviewer of many journals, Citation Index over 200. She has cited in many monographs and she is One of the World's 100 Top Scientists- IBC Cambridge.