Plenary Lecture

Biotransistors, voltage gated nanopore forming proteins, and their application in drug delivery, practical and theoretical approach

Assistant Professor Hamid Mobasheri
Laboratory of Membrane Biophysics,
Institute of Biochemistry and Biophysics,
University of Tehran,
PO Box 13145-1384, Tehran
IRAN
E-mail: h.mobasheri@ibb.ut.ac.ir
Website: http://www.ut.ac.ir/~mobasheri

Abstract: The fundamental physics of biological matters provides vast opportunities to control manipulate and organize its vital activities electronically. The traffic of different hydrophilic solutes, nutrients, drugs, and to some extent genetic materials is being conducted by pore forming proteins situated in hydrophobic barrier made by cell membrane. Similar to transistors these proteins are biased in certain manner in the membrane and are gated by means of its potential difference. Though the setting up the potential difference between inside and outside of the cell is well implemented by these channels, they, themselves are influenced by the very same potential. Furthermore, there are different means to change their conductance, gating pattern, selectivity and working status in general.
Working at single molecular level, the gating dynamics of these channels were studied in real time, and the situation was manipulated in a way to make them translocate molecules they wouldn’t pass otherwise. Recordings of the channel activities in different physicochemical condition and also in presence and absence of different antibiotics made it possible to find the way to control these nano-valves.
The current traces then were used to be analyzed theoretically and mathematically to further understand the way these valves behave at molecular level and to model their molecular dynamics in real time.
Consequently, it seams biomedical electronics has to dealt with such a systems in order to manipulate the living systems electronically, and to evaluate data using algorithms and theorems to learn the modern approaches in treatment of diseases that will be further discussed here.



Brief Biography of the Speaker:
Hamid Mobasheri
PhD in Biophysics,
Born in 1960, Iranian, Married and have 3 Children
(2008)

Member of: American Biophysical Society, British Biophysical Society, Australia Biophysical Society, ELSO

Postgraduate courses taught:
Computer in Biology
Membrane Biophysics
Cellular Biophysics
Biophysics for (Immunologits, Medical physists, Physiologists, Biotechnologists, etc)

Achievements:
MSRT Scholarship
Distinguished Postgraduate student of 2000
Welcome Trust Post Doctrate Grant
Marquis Who’s Who (USA) nominate as one of distinguished scientist of 2004
IBC (UK) nominate as one of distinguished scientist of 2006

Research fields:
Biosensors and biophysics of nanopore forming protein ion channel, Biotransistors
Computational and theoretical biophysics of channel gating
Biophysics of nerve regeneration and spinal cord injuries
Biotransistors application in drug delivery and DNA/RNA sequencing
Biophysics of electric and magnetic field effects on neural cell culture
Biophysics of molecular effects of high frequency electromagnetic fields
Biomaterials and nerve regeneration