Plenary Lecture

Medical Big Data and Knowledge Discovery

Professor Hiroshi Tanaka
Department of Bioinformatics
Medical Research Institute
Tokyo Medical and Dental University
Japan
E-mail: tanaka@bioinfo.tmd.ac.jp

Abstract: With the rapid advance in clinical application of the next generation sequencer (NGS) of human genome, a great deal of interests is now being attracted in accumulation, analysis and knowledge discovery of clinical Big Data, which integrates a vast amount of molecular information such as whole genome and exome sequencing together with conventional clinic-pathological phenotypic information stored in electronic medical record (EMR). A considerable number of hospitals in US, using NGS, now try to discover the mutation of unknown disease causative genes, driver mutations of cancer, or to avoid the misuse of drug by inquiring the polymorphism of drug metabolizing gene of the paitent, in clinical routines, pursuing to realize genome/omics medicine. With this situation in mind, NIH in US started the national initiative named “Big Data to Knowledge” To explore the appropriate therapy, Big Data database with self-learning ability is crucially necessary. In this talk, I will present the international situation as well as our project to promote the data science in biomedical Big Data.

Brief Biography of the Speaker: Prof. Tanaka obtained a BS and MS degree from Mathematical Engineering, University of Tokyo (Japan), in 1974 and 1976, respectively. He got Dr. Med. from graduate school of medicine, University of Tokyo, in 1981 and Ph.D. in computer science from graduate school of engineering, University of Tokyo, in 1983. He was installed as an assistant professor of medicine, University of Tokyo in 1982. He was a visiting scientist at MIT laboratory of computer science during 1990. He was installed as a professor of bioinformatics, Medical Research Institute, Tokyo Medical and Dental University in 1991. He was the director of Information Center for Medicine in Tokyo Medical and Dental University from 1995-2010. He was Dean of School of Biomedical Science from 2006 to 2010. He worked as the president of Japan Association of Medical Informatics from 2003-2007. He is now chairman of Chem-Bioinformatics association and also that of the Japan association of Omics-based medicine, acting as one of the leaders of genomic medicine and translational bioinformatics in Japan.

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